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HPLC-Based Activity Profiling: Discovery of Piperine as a Positive GABA(A) Receptor Modulator Targeting a Benzodiazepine-Independent Binding Site

A plant extract library was screened for GABA(A) receptor activity making use of a two-microelectrode voltage clamp assay on Xenopus laevis oocytes. An ethyl acetate extract of black pepper fruits [Piper nigrum L. (Piperaceae) 100 μg/mL] potentiated GABA-induced chloride currents through GABA(A) rec...

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Detalhes bibliográficos
Main Authors: Zaugg, Janine, Baburin, Igor, Strommer, Barbara, Kim, Hyun-Jung, Hering, Steffen, Hamburger, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196983/
https://ncbi.nlm.nih.gov/pubmed/20085307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np900656g
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