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HPLC-Based Activity Profiling Approach for the Discovery of GABA(A) Receptor Ligands using an Automated Two Microelectrode Voltage Clamp Assay on Xenopus Oocytes
An approach for rapid HPLC-based profiling for new GABA(A) ligands of natural origin has been developed. Active extracts are separated by a single injection of 3 – 10 mg of extract onto a semi-preparative (150 × 10 mm i.d.) HPLC column with gradient elution and time-based fractionation. The microfra...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3196969/ https://ncbi.nlm.nih.gov/pubmed/18543148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-2008-1074491 |
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