A Multicenter, Phase I, Dose-Escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics of Etirinotecan Pegol in Patients with Refractory Solid Tumors

PURPOSE: This study was designed to establish the maximum tolerated dose (MTD) and to evaluate tolerability, pharmacokinetics, and antitumor activity of etirinotecan pegol. EXPERIMENTAL DESIGN: Patients with refractory solid malignancies were enrolled and assigned to escalating-dose cohorts. Patient...

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Bibliografski detalji
Glavni autori: Jameson, Gayle S., Hamm, John T., Weiss, Glen J., Alemany, Carlos, Anthony, Stephen, Basche, Michele, Ramanathan, Ramesh K., Borad, Mitesh J., Tibes, Raoul, Cohn, Allen, Hinshaw, Ioana, Jotte, Robert, Rosen, Lee S., Hoch, Ute, Eldon, Michael A., Medve, Robert, Schroeder, Katrina, White, Erica, Von Hoff, Daniel D.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104496/
https://ncbi.nlm.nih.gov/pubmed/23136196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1201
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