A Multicenter, Phase I, Dose-Escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics of Etirinotecan Pegol in Patients with Refractory Solid Tumors

PURPOSE: This study was designed to establish the maximum tolerated dose (MTD) and to evaluate tolerability, pharmacokinetics, and antitumor activity of etirinotecan pegol. EXPERIMENTAL DESIGN: Patients with refractory solid malignancies were enrolled and assigned to escalating-dose cohorts. Patient...

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Autori principali: Jameson, Gayle S., Hamm, John T., Weiss, Glen J., Alemany, Carlos, Anthony, Stephen, Basche, Michele, Ramanathan, Ramesh K., Borad, Mitesh J., Tibes, Raoul, Cohn, Allen, Hinshaw, Ioana, Jotte, Robert, Rosen, Lee S., Hoch, Ute, Eldon, Michael A., Medve, Robert, Schroeder, Katrina, White, Erica, Von Hoff, Daniel D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104496/
https://ncbi.nlm.nih.gov/pubmed/23136196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1201
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