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Nonclinical pharmacokinetics and activity of etirinotecan pegol (NKTR-102), a long-acting topoisomerase 1 inhibitor, in multiple cancer models
PURPOSE: The aim of the study was to demonstrate the activity of etirinotecan pegol, a polymer conjugate of irinotecan, in multiple human tumor models and to establish both the pharmacokinetic/pharmacodynamics (PK/PD) relationship and clinical relevance of the findings. EXPERIMENTAL DESIGN: Anti-tum...
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| Publicado no: | Cancer Chemother Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4236622/ https://ncbi.nlm.nih.gov/pubmed/25228368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2577-7 |
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