A Multicenter, Phase I, Dose-Escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics of Etirinotecan Pegol in Patients with Refractory Solid Tumors

PURPOSE: This study was designed to establish the maximum tolerated dose (MTD) and to evaluate tolerability, pharmacokinetics, and antitumor activity of etirinotecan pegol. EXPERIMENTAL DESIGN: Patients with refractory solid malignancies were enrolled and assigned to escalating-dose cohorts. Patient...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jameson, Gayle S., Hamm, John T., Weiss, Glen J., Alemany, Carlos, Anthony, Stephen, Basche, Michele, Ramanathan, Ramesh K., Borad, Mitesh J., Tibes, Raoul, Cohn, Allen, Hinshaw, Ioana, Jotte, Robert, Rosen, Lee S., Hoch, Ute, Eldon, Michael A., Medve, Robert, Schroeder, Katrina, White, Erica, Von Hoff, Daniel D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104496/
https://ncbi.nlm.nih.gov/pubmed/23136196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1201
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