Etirinotecan pegol administration is associated with lower incidences of neutropenia compared to irinotecan administration

PURPOSE: The relationship between incidences of neutropenia and 10-hydroxy-7-ethyl camptothecin (SN38) exposure was explored using SN38 pharmacokinetic and neutrophil count data from toxicology studies of etirinotecan pegol (EP) and irinotecan in beagle dogs. METHODS: Dogs received four weekly intra...

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Vydáno v:Cancer Chemother Pharmacol
Hlavní autoři: Sy, S. Kenneth, Sweeney, Theresa D., Ji, Chunmei, Hoch, Ute, Eldon, Michael A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2016
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225190/
https://ncbi.nlm.nih.gov/pubmed/27904955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-016-3192-6
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