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Etirinotecan pegol administration is associated with lower incidences of neutropenia compared to irinotecan administration
PURPOSE: The relationship between incidences of neutropenia and 10-hydroxy-7-ethyl camptothecin (SN38) exposure was explored using SN38 pharmacokinetic and neutrophil count data from toxicology studies of etirinotecan pegol (EP) and irinotecan in beagle dogs. METHODS: Dogs received four weekly intra...
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| Udgivet i: | Cancer Chemother Pharmacol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Springer Berlin Heidelberg
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5225190/ https://ncbi.nlm.nih.gov/pubmed/27904955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-016-3192-6 |
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