Transgenic overexpression of the presynaptic choline transporter elevates acetylcholine levels and augments motor endurance

The hemicholinium-3 (HC-3) sensitive, high-affinity choline transporter (CHT) sustains cholinergic signaling via the presynaptic uptake of choline derived from dietary sources or from acetylcholinesterase (AChE)-mediated hydrolysis of acetylcholine (ACh). Loss of cholinergic signaling capacity is as...

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Autores principales: Holmstrand, Ericka C., Lund, David, Cherian, Ajeesh Koshy, Wright, Jane, Martin, Rolicia F., Ennis, Elizabeth A., Stanwood, Gregg D., Sarter, Martin, Blakely, Randy D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104494/
https://ncbi.nlm.nih.gov/pubmed/24274995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2013.11.008
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