Macrolide antibiotics allosterically predispose the ribosome for translation arrest

Translation arrest directed by nascent peptides and small cofactors controls expression of important bacterial and eukaryotic genes, including antibiotic resistance genes, activated by binding of macrolide drugs to the ribosome. Previous studies suggested that specific interactions between the nasce...

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Detalhes bibliográficos
Main Authors: Sothiselvam, Shanmugapriya, Liu, Bo, Han, Wei, Ramu, Haripriya, Klepacki, Dorota, Atkinson, Gemma Catherine, Brauer, Age, Remm, Maido, Tenson, Tanel, Schulten, Klaus, Vázquez-Laslop, Nora, Mankin, Alexander S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103360/
https://ncbi.nlm.nih.gov/pubmed/24961372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403586111
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