Macrolide antibiotics allosterically predispose the ribosome for translation arrest

Translation arrest directed by nascent peptides and small cofactors controls expression of important bacterial and eukaryotic genes, including antibiotic resistance genes, activated by binding of macrolide drugs to the ribosome. Previous studies suggested that specific interactions between the nasce...

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Hlavní autoři: Sothiselvam, Shanmugapriya, Liu, Bo, Han, Wei, Ramu, Haripriya, Klepacki, Dorota, Atkinson, Gemma Catherine, Brauer, Age, Remm, Maido, Tenson, Tanel, Schulten, Klaus, Vázquez-Laslop, Nora, Mankin, Alexander S.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103360/
https://ncbi.nlm.nih.gov/pubmed/24961372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403586111
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