mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

Mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cell metabolism and autophagy. Despite widespread clinical use of mTORC1 inhibitors, the role of mTORC1 in renal tubular function and kidney homeostasis remains elusive. By using constitutive and inducible deletion of conditional...

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Autori principali: Grahammer, Florian, Haenisch, Nora, Steinhardt, Frederic, Sandner, Lukas, Roerden, Malte, Arnold, Frederic, Cordts, Tomke, Wanner, Nicola, Reichardt, Wilfried, Kerjaschki, Dontscho, Ruegg, Markus A., Hall, Michael N., Moulin, Pierre, Busch, Hauke, Boerries, Melanie, Walz, Gerd, Artunc, Ferruh, Huber, Tobias B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103333/
https://ncbi.nlm.nih.gov/pubmed/24958889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402352111
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