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mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

Mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cell metabolism and autophagy. Despite widespread clinical use of mTORC1 inhibitors, the role of mTORC1 in renal tubular function and kidney homeostasis remains elusive. By using constitutive and inducible deletion of conditional...

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Bibliografski detalji
Glavni autori: Grahammer, Florian, Haenisch, Nora, Steinhardt, Frederic, Sandner, Lukas, Roerden, Malte, Arnold, Frederic, Cordts, Tomke, Wanner, Nicola, Reichardt, Wilfried, Kerjaschki, Dontscho, Ruegg, Markus A., Hall, Michael N., Moulin, Pierre, Busch, Hauke, Boerries, Melanie, Walz, Gerd, Artunc, Ferruh, Huber, Tobias B.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103333/
https://ncbi.nlm.nih.gov/pubmed/24958889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402352111
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