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Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy

Phosphatase and tensin homolog (PTEN) loss is associated with genomic instability. APE1 is a key player in DNA base excision repair (BER) and an emerging drug target in cancer. We have developed small molecule inhibitors against APE1 repair nuclease activity. In the current study we explored a synth...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Abbotts, Rachel, Jewell, Rosalyn, Nsengimana, Jérémie, Maloney, David J, Simeonov, Anton, Seedhouse, Claire, Elliott, Faye, Laye, Jon, Walker, Christy, Jadhav, Ajit, Grabowska, Anna, Ball, Graham, Patel, Poulam M, Newton-Bishop, Julia, Wilson, David M, Madhusudan, Srinivasan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals LLC 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102809/
https://ncbi.nlm.nih.gov/pubmed/24830350
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