Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy

Phosphatase and tensin homolog (PTEN) loss is associated with genomic instability. APE1 is a key player in DNA base excision repair (BER) and an emerging drug target in cancer. We have developed small molecule inhibitors against APE1 repair nuclease activity. In the current study we explored a synth...

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Detalhes bibliográficos
Main Authors: Abbotts, Rachel, Jewell, Rosalyn, Nsengimana, Jérémie, Maloney, David J, Simeonov, Anton, Seedhouse, Claire, Elliott, Faye, Laye, Jon, Walker, Christy, Jadhav, Ajit, Grabowska, Anna, Ball, Graham, Patel, Poulam M, Newton-Bishop, Julia, Wilson, David M, Madhusudan, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102809/
https://ncbi.nlm.nih.gov/pubmed/24830350
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