Knock-In Reporter Mice Demonstrate that DNA Repair by Non-homologous End Joining Declines with Age

Accumulation of genome rearrangements is a characteristic of aged tissues. Since genome rearrangements result from faulty repair of DNA double strand breaks (DSBs), we hypothesized that DNA DSB repair becomes less efficient with age. The Non-Homologous End Joining (NHEJ) pathway repairs a majority o...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Vaidya, Amita, Mao, Zhiyong, Tian, Xiao, Spencer, Brianna, Seluanov, Andrei, Gorbunova, Vera
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102425/
https://ncbi.nlm.nih.gov/pubmed/25033455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004511
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge