Knock-In Reporter Mice Demonstrate that DNA Repair by Non-homologous End Joining Declines with Age

Accumulation of genome rearrangements is a characteristic of aged tissues. Since genome rearrangements result from faulty repair of DNA double strand breaks (DSBs), we hypothesized that DNA DSB repair becomes less efficient with age. The Non-Homologous End Joining (NHEJ) pathway repairs a majority o...

Full description

Saved in:
Bibliographic Details
Main Authors: Vaidya, Amita, Mao, Zhiyong, Tian, Xiao, Spencer, Brianna, Seluanov, Andrei, Gorbunova, Vera
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102425/
https://ncbi.nlm.nih.gov/pubmed/25033455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004511
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items