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Knock-In Reporter Mice Demonstrate that DNA Repair by Non-homologous End Joining Declines with Age
Accumulation of genome rearrangements is a characteristic of aged tissues. Since genome rearrangements result from faulty repair of DNA double strand breaks (DSBs), we hypothesized that DNA DSB repair becomes less efficient with age. The Non-Homologous End Joining (NHEJ) pathway repairs a majority o...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4102425/ https://ncbi.nlm.nih.gov/pubmed/25033455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004511 |
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