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Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR

The M2 protein of influenza viruses forms an acid-activated tetrameric proton channel. We used solid-state nuclear magnetic resonance spectroscopy to determine the structure and functional dynamics of the pH-sensing and proton-selective histidine-37 in M2 bound to a cholesterol-containing virus-enve...

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Autors principals: Hu, Fanghao, Luo, Wenbin, Hong, Mei
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102303/
https://ncbi.nlm.nih.gov/pubmed/20966251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1191714
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