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Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR
The M2 protein of influenza viruses forms an acid-activated tetrameric proton channel. We used solid-state nuclear magnetic resonance spectroscopy to determine the structure and functional dynamics of the pH-sensing and proton-selective histidine-37 in M2 bound to a cholesterol-containing virus-enve...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4102303/ https://ncbi.nlm.nih.gov/pubmed/20966251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1191714 |
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