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Structural Basis for Asymmetric Conductance of the Influenza M2 Proton Channel Investigated by Solid-State NMR Spectroscopy
The influenza M2 protein forms an acid-activated proton channel that is essential for virus replication. The transmembrane H37 selects for protons under low external pH (pH(out)) while W41 ensures proton conduction only from the N-terminus to the C-terminus and prevents reverse current under low int...
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| Опубликовано в: : | J Mol Biol |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5761075/ https://ncbi.nlm.nih.gov/pubmed/28535993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.05.015 |
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