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Structural Basis for Asymmetric Conductance of the Influenza M2 Proton Channel Investigated by Solid-State NMR Spectroscopy
The influenza M2 protein forms an acid-activated proton channel that is essential for virus replication. The transmembrane H37 selects for protons under low external pH (pH(out)) while W41 ensures proton conduction only from the N-terminus to the C-terminus and prevents reverse current under low int...
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| Vydáno v: | J Mol Biol |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5761075/ https://ncbi.nlm.nih.gov/pubmed/28535993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.05.015 |
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