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Structural Basis for Asymmetric Conductance of the Influenza M2 Proton Channel Investigated by Solid-State NMR Spectroscopy

The influenza M2 protein forms an acid-activated proton channel that is essential for virus replication. The transmembrane H37 selects for protons under low external pH (pH(out)) while W41 ensures proton conduction only from the N-terminus to the C-terminus and prevents reverse current under low int...

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Bibliografiske detaljer
Udgivet i:J Mol Biol
Main Authors: Mandala, Venkata S., Liao, Shu Yu, Kwon, Byungsu, Hong, Mei
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5761075/
https://ncbi.nlm.nih.gov/pubmed/28535993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.05.015
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