Effects of human SAMHD1 Polymorphisms on HIV-1 Susceptibility

SAMHD1 is a human restriction factor that prevents efficient infection of macrophages, dendritic cells and resting CD4+ T cells by HIV-1. Here we explored the antiviral activity and biochemical properties of human SAMHD1 polymorphisms. Our studies focused on human SAMHD1 polymorphisms that were prev...

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Bibliografiske detaljer
Main Authors: White, Tommy E., Brandariz-Nuñez, Alberto, Valle-Casuso, Jose Carlos, Knowlton, Caitlin, Kim, Baek, Sawyer, Sara L., Diaz-Griffero, Felipe
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101048/
https://ncbi.nlm.nih.gov/pubmed/25010268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.04.023
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