Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1

BACKGROUND: SAMHD1 is a restriction factor that potently blocks infection by HIV-1 and other retroviruses. We have previously demonstrated that SAMHD1 oligomerizes in mammalian cells by immunoprecipitation. Here we investigated the contribution of SAMHD1 oligomerization to retroviral restriction. RE...

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Hauptverfasser: Brandariz-Nuñez, Alberto, Valle-Casuso, Jose Carlos, White, Tommy E, Nguyen, Laura, Bhattacharya, Akash, Wang, Zhonghua, Demeler, Borries, Amie, Sarah, Knowlton, Caitlin, Kim, Baek, Ivanov, Dmitri N, Diaz-Griffero, Felipe
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882887/
https://ncbi.nlm.nih.gov/pubmed/24219908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-131
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