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A SAMHD1 mutation associated with Aicardi-Goutières Syndrome uncouples the Ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans
Mutations in the human SAMHD1 gene are known to correlate with the development of the Aicardi-Goutières Syndrome (AGS), which is an inflammatory encephalopathy that exhibits neurological dysfunction characterized by increased production of type I interferon (IFN); this evidence has lead to the conce...
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| Publicado no: | Hum Mutat |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5738905/ https://ncbi.nlm.nih.gov/pubmed/28229507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.23201 |
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