Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac

BACKGROUND: SAMHD1 is a nuclear protein that blocks lentiviral infection before reverse transcription in macrophages and dendritic cells. The viral accessory protein Vpx overcomes the SAMHD1-mediated lentiviral block by inducing its proteasomal degradation. RESULTS: Here, we identified the nuclear l...

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Autori principali: Brandariz-Nuñez, Alberto, Valle-Casuso, Jose Carlos, White, Tommy E, Laguette, Nadine, Benkirane, Monsef, Brojatsch, Jurgen, Diaz-Griffero, Felipe
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410799/
https://ncbi.nlm.nih.gov/pubmed/22691373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-49
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