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Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac
BACKGROUND: SAMHD1 is a nuclear protein that blocks lentiviral infection before reverse transcription in macrophages and dendritic cells. The viral accessory protein Vpx overcomes the SAMHD1-mediated lentiviral block by inducing its proteasomal degradation. RESULTS: Here, we identified the nuclear l...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3410799/ https://ncbi.nlm.nih.gov/pubmed/22691373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-9-49 |
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