Expansion and Homing of Adoptively Transferred Human NK Cells in Immunodeficient Mice Varies with Product Preparation and In Vivo Cytokine Administration: Implications for Clinical Therapy

NK cell efficacy correlates with in vivo proliferation and we hypothesize that NK cell product manipulations may optimize this endpoint. Xenotransplantation was used to compare GMP grade freshly activated NK cells (FA-NK) and ex vivo expanded NK cells (Ex-NK). Cells were infused into NSG mice follow...

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Detalhes bibliográficos
Main Authors: Miller, Jeffrey S., Rooney, Cliona M, Curtsinger, Julie, McElmurry, Ron, McCullar, Valarie, Verneris, Michael R., Lapteva, Natalia, McKenna, David, Wagner, John E., Blazar, Bruce R., Tolar, Jakub
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4099265/
https://ncbi.nlm.nih.gov/pubmed/24816582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2014.05.004
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