NK cell killing of AML and ALL blasts by Killer-Immunoglobulin Receptor (KIR) negative NK cells after NKG2A and LIR-1 blockade

Although NK cell alloreactivity has been dominated by studies of KIR, we hypothesized that NKG2A and LIR-1, present on 53±13% and 36±18% of normal NK cells, plays a role in NK cell killing of primary leukemia targets. KIR(−) cells, which comprise nearly half of the circulating NK cell population, ex...

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Detalhes bibliográficos
Main Authors: Godal, Robert, Bachanova, Veronika, Gleason, Michelle, McCullar, Valarie, Yun, Gong H., Cooley, Sarah, Verneris, Michael R., McGlave, Philip B., Miller, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854246/
https://ncbi.nlm.nih.gov/pubmed/20139023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2010.01.019
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