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ACTIVATED NOTCH SUPPORTS DEVELOPMENT OF CYTOKINE PRODUCING NK CELLS WHICH ARE HYPORESPONSIVE AND FAIL TO ACQUIRE NK CELL EFFECTOR FUNCTIONS

Natural Killer (NK) cells are powerful effectors of cytotoxicity against “stressed” cells. They also produce cytokines and chemokines to activate the adaptive immune response. Understanding NK cell development and maturation may have implications for cancer therapy and for immunity against infection...

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Detalhes bibliográficos
Main Authors: Bachanova, Veronika, McCullar, Valarie, Lenvik, Todd, Wangen, Rosanna, Peterson, Karen A., Ankarlo, Dave EM., Panoskaltsis-Mortari, Angela, Wagner, John E., Miller, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655654/
https://ncbi.nlm.nih.gov/pubmed/19167678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2008.11.031
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