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ACTIVATED NOTCH SUPPORTS DEVELOPMENT OF CYTOKINE PRODUCING NK CELLS WHICH ARE HYPORESPONSIVE AND FAIL TO ACQUIRE NK CELL EFFECTOR FUNCTIONS
Natural Killer (NK) cells are powerful effectors of cytotoxicity against “stressed” cells. They also produce cytokines and chemokines to activate the adaptive immune response. Understanding NK cell development and maturation may have implications for cancer therapy and for immunity against infection...
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Main Authors: | , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2655654/ https://ncbi.nlm.nih.gov/pubmed/19167678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2008.11.031 |
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