Bispecific and trispecific killer cell engagers directly activate human NK cells through CD16 signaling and induce cytotoxicity and cytokine production

This study evaluates the mechanism by which bispecific and trispecific killer cell engagers (BiKEs and TriKEs) act to trigger human NK cell effector function and investigates their ability to induce NK cell cytokine and chemokine production against human B-cell leukemia. We examined the ability of B...

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Detalhes bibliográficos
Main Authors: Gleason, Michelle K., Verneris, Michael R., Todhunter, Deborah A., Zhang, Bin, McCullar, Valarie, Zhou, Sophia X., Panoskaltsis-Mortari, Angela, Weiner, Louis M., Vallera, Daniel A., Miller, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519950/
https://ncbi.nlm.nih.gov/pubmed/23075808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0692
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