IL-15 Trispecific Killer Engagers (TriKEs) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function

PURPOSE: The effectiveness of NK cell infusions to induce leukemic remission is limited by lack of both antigen specificity and in vivo expansion. To address the first issue we previously generated a bispecific killer engager (BiKE) containing single chain scFV against CD16 and CD33 to create an imm...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Vallera, Daniel A., Felices, Martin, McElmurry, Ron, McCullar, Valarie, Zhou, Xianzheng, Schmohl, Joerg Uwe, Zhang, Bin, Lenvik, Alexander J. L., Panoskaltsis-Mortari, Angela, Verneris, Michael R., Tolar, Jakub, Cooley, Sarah, Weisdorf, Daniel J., Blazar, Bruce R., Miller, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947440/
https://ncbi.nlm.nih.gov/pubmed/26847056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2710
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