IL-15 Trispecific Killer Engagers (TriKEs) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function

PURPOSE: The effectiveness of NK cell infusions to induce leukemic remission is limited by lack of both antigen specificity and in vivo expansion. To address the first issue we previously generated a bispecific killer engager (BiKE) containing single chain scFV against CD16 and CD33 to create an imm...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Vallera, Daniel A., Felices, Martin, McElmurry, Ron, McCullar, Valarie, Zhou, Xianzheng, Schmohl, Joerg Uwe, Zhang, Bin, Lenvik, Alexander J. L., Panoskaltsis-Mortari, Angela, Verneris, Michael R., Tolar, Jakub, Cooley, Sarah, Weisdorf, Daniel J., Blazar, Bruce R., Miller, Jeffrey S.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947440/
https://ncbi.nlm.nih.gov/pubmed/26847056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2710
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires