Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect

NK cell–based immunotherapies have been gaining traction in the clinic for treatment of cancer. IL-15 is currently being used in number of clinical trials to improve NK cell expansion and function. The objective of this study is to evaluate the effect of repetitive IL-15 exposure on NK cells. An in...

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Pubblicato in:JCI Insight
Autori principali: Felices, Martin, Lenvik, Alexander J., McElmurry, Ron, Chu, Sami, Hinderlie, Peter, Bendzick, Laura, Geller, Melissa A., Tolar, Jakub, Blazar, Bruce R., Miller, Jeffrey S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821201/
https://ncbi.nlm.nih.gov/pubmed/29415897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96219
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