Ineffectual Targeting of HIV-1 Nef by Cytotoxic T Lymphocytes in Acute Infection Results in No Functional Impairment or Viremia Reduction

The human immunodeficiency virus type 1 (HIV-1) accessory protein Nef is heavily targeted by CD8(+) T lymphocytes (CTLs) during acute infection and therefore is included in many candidate vaccines. We investigated whether CTL targeting of Nef during acute infection contributes to immune control by d...

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Bibliographic Details
Main Authors: De La Cruz, Justin, Vollbrecht, Thomas, Frohnen, Patricia, Ng, Hwee L., Daar, Eric S., Yang, Otto O., Lewis, Martha J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097801/
https://ncbi.nlm.nih.gov/pubmed/24789790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00482-14
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