Impaired Nef Function Is Associated with Early Control of HIV-1 Viremia

Host and viral factors influence the HIV-1 infection course. Reduced Nef function has been observed in HIV-1 controllers during the chronic phase, but the kinetics and mechanisms of Nef attenuation in such individuals remain unclear. We examined plasma RNA-derived Nef clones from 10 recently infecte...

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Autores principales: Kuang, Xiaomei T., Li, Xiaoguang, Anmole, Gursev, Mwimanzi, Philip, Shahid, Aniqa, Le, Anh Q., Chong, Louise, Qian, Hua, Miura, Toshiyuki, Markle, Tristan, Baraki, Bemuluyigza, Connick, Elizabeth, Daar, Eric S., Jessen, Heiko, Kelleher, Anthony D., Little, Susan, Markowitz, Martin, Pereyra, Florencia, Rosenberg, Eric S., Walker, Bruce D., Ueno, Takamasa, Brumme, Zabrina L., Brockman, Mark A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Pathogenesis and Immunity
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136354/
https://ncbi.nlm.nih.gov/pubmed/24965469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01334-14
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