Immune Selection In Vitro Reveals Human Immunodeficiency Virus Type 1 Nef Sequence Motifs Important for Its Immune Evasion Function In Vivo

Human immunodeficiency virus type 1 (HIV-1) Nef downregulates major histocompatibility complex class I (MHC-I), impairing the clearance of infected cells by CD8(+) cytotoxic T lymphocytes (CTLs). While sequence motifs mediating this function have been determined by in vitro mutagenesis studies of la...

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Bibliographische Detailangaben
Hauptverfasser: Lewis, Martha J., Lee, Patricia, Ng, Hwee L., Yang, Otto O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416312/
https://ncbi.nlm.nih.gov/pubmed/22553319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00878-12
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