Differential Impairment of Lytic and Cytokine Functions in Senescent Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes

Telomere length is abnormally short in the CD8(+) T-cell compartment of human immunodeficiency virus type 1 (HIV-1)-infected persons, likely because of chronic cell turnover. Although clonal exhaustion of CD8(+) cytotoxic T lymphocytes (CTL) has been proposed as a mechanism for loss of antigen-speci...

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Detalhes bibliográficos
Main Authors: Dagarag, Mirabelle, Ng, Hwee, Lubong, Rachel, Effros, Rita B., Yang, Otto O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC149786/
https://ncbi.nlm.nih.gov/pubmed/12584333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.5.3077-3083.2003
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