Differential Impairment of Lytic and Cytokine Functions in Senescent Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes

Telomere length is abnormally short in the CD8(+) T-cell compartment of human immunodeficiency virus type 1 (HIV-1)-infected persons, likely because of chronic cell turnover. Although clonal exhaustion of CD8(+) cytotoxic T lymphocytes (CTL) has been proposed as a mechanism for loss of antigen-speci...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Dagarag, Mirabelle, Ng, Hwee, Lubong, Rachel, Effros, Rita B., Yang, Otto O.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Pathogenesis and Immunity
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12584333/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.5.3077-3083.2003
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