Restoration of PTEN Activity Decreases Metastases in an Orthotopic Model of Colon Cancer

BACKGROUND: Mutational loss of tumor suppressor phosphatase and tensin homologue deleted on chromosome ten (PTEN) is associated with malignant progression in many cancers including colorectal cancer (CRC). PTEN is involved in negatively regulating the Phosphatidylinositol 3-kinase (PI3K)/AKT oncogen...

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Autori principali: Chowdhury, Sanjib, Ongchin, Melanie, Wan, Guanghua, Sharratt, Elizabeth, Brattain, Michael G., Rajput, Ashwani
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096772/
https://ncbi.nlm.nih.gov/pubmed/23623571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2013.03.035
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