Restoration of PTEN Activity Decreases Metastases in an Orthotopic Model of Colon Cancer

BACKGROUND: Mutational loss of tumor suppressor phosphatase and tensin homologue deleted on chromosome ten (PTEN) is associated with malignant progression in many cancers including colorectal cancer (CRC). PTEN is involved in negatively regulating the Phosphatidylinositol 3-kinase (PI3K)/AKT oncogen...

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Detaylı Bibliyografya
Asıl Yazarlar: Chowdhury, Sanjib, Ongchin, Melanie, Wan, Guanghua, Sharratt, Elizabeth, Brattain, Michael G., Rajput, Ashwani
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096772/
https://ncbi.nlm.nih.gov/pubmed/23623571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2013.03.035
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