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Restoration of PTEN Activity Decreases Metastases in an Orthotopic Model of Colon Cancer
BACKGROUND: Mutational loss of tumor suppressor phosphatase and tensin homologue deleted on chromosome ten (PTEN) is associated with malignant progression in many cancers including colorectal cancer (CRC). PTEN is involved in negatively regulating the Phosphatidylinositol 3-kinase (PI3K)/AKT oncogen...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4096772/ https://ncbi.nlm.nih.gov/pubmed/23623571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2013.03.035 |
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