Chemically Accessible Hsp90 Inhibitor That Does Not Induce a Heat Shock Response

[Image: see text] Recent cancer therapies have focused on targeting biology networks through a single regulatory protein. Heat shock protein 90 (hsp90) is an ideal oncogenic target as it regulates over 400 client proteins and cochaperones. However, clinical inhibitors of hsp90 have had limited succe...

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Bibliografiske detaljer
Main Authors: Koay, Yen Chin, McConnell, Jeanette R., Wang, Yao, Kim, Seong Jong, Buckton, Laura K., Mansour, Flora, McAlpine, Shelli R.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094262/
https://ncbi.nlm.nih.gov/pubmed/25050163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500114p
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