Secreted Histidyl-tRNA Synthetase Splice Variants Elaborate Major Epitopes for Autoantibodies in Inflammatory Myositis

Inflammatory and debilitating myositis and interstitial lung disease are commonly associated with autoantibodies (anti-Jo-1 antibodies) to cytoplasmic histidyl-tRNA synthetase (HisRS). Anti-Jo-1 antibodies from different disease-afflicted patients react mostly with spatially separated epitopes in th...

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Hauptverfasser: Zhou, Jie J., Wang, Feng, Xu, Zhiwen, Lo, Wing-Sze, Lau, Ching-Fun, Chiang, Kyle P., Nangle, Leslie A., Ashlock, Melissa A., Mendlein, John D., Yang, Xiang-Lei, Zhang, Mingjie, Schimmel, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094037/
https://ncbi.nlm.nih.gov/pubmed/24898250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C114.571026
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