Histidyl–tRNA Synthetase and Asparaginyl–tRNA Synthetase, Autoantigens in Myositis, Activate Chemokine Receptors on T Lymphocytes and Immature Dendritic Cells

Autoantibodies to histidyl–tRNA synthetase (HisRS) or to alanyl–, asparaginyl–, glycyl–, isoleucyl–, or threonyl–tRNA synthetase occur in ∼25% of patients with polymyositis or dermatomyositis. We tested the ability of several aminoacyl–tRNA synthetases to induce leukocyte migration. HisRS induced CD...

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Main Authors: Howard, O.M. Zack, Dong, Hui Fang, Yang, De, Raben, Nina, Nagaraju, Kanneboyina, Rosen, Antony, Casciola-Rosen, Livia, Härtlein, Michael, Kron, Michael, Yang, David, Yiadom, Kwabena, Dwivedi, Sunita, Plotz, Paul H., Oppenheim, Joost J.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2002
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194054/
https://ncbi.nlm.nih.gov/pubmed/12235211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020186
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