Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing

Aminoacyl-tRNA synthetases (AARSs) catalyze aminoacylation of tRNAs in the cytoplasm. Surprisingly, AARSs also have critical extracellular and nuclear functions. Evolutionary pressure for new functions might be manifested by splice variants that skip only an internal catalytic domain (CD) and link n...

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Autores principales: Xu, Zhiwen, Wei, Zhiyi, Zhou, Jie J., Ye, Fei, Lo, Wing-Sze, Wang, Feng, Lau, Ching-Fun, Wu, Jingjing, Nangle, Leslie A., Chiang, Kyle P., Yang, Xiang-Lei, Zhang, Mingjie, Schimmel, Paul
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485694/
https://ncbi.nlm.nih.gov/pubmed/22958643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.001
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