Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing

Aminoacyl-tRNA synthetases (AARSs) catalyze aminoacylation of tRNAs in the cytoplasm. Surprisingly, AARSs also have critical extracellular and nuclear functions. Evolutionary pressure for new functions might be manifested by splice variants that skip only an internal catalytic domain (CD) and link n...

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Bibliografiske detaljer
Main Authors: Xu, Zhiwen, Wei, Zhiyi, Zhou, Jie J., Ye, Fei, Lo, Wing-Sze, Wang, Feng, Lau, Ching-Fun, Wu, Jingjing, Nangle, Leslie A., Chiang, Kyle P., Yang, Xiang-Lei, Zhang, Mingjie, Schimmel, Paul
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485694/
https://ncbi.nlm.nih.gov/pubmed/22958643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.001
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