Human tRNA Synthetase Catalytic Nulls with Diverse Functions

Genetic efficiency in higher organisms depends on mechanisms to create multiple functions from single genes. To investigate this question for an enzyme family, we chose aminoacyl tRNA synthetases (AARSs). They are exceptional in their progressive and accretive proliferation of noncatalytic domains a...

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Detalhes bibliográficos
Main Authors: Lo, Wing-Sze, Gardiner, Elisabeth, Xu, Zhiwen, Lau, Ching-Fun, Wang, Feng, Zhou, Jie, Mendlein, John D., Nangle, Leslie A., Chiang, Kyle P., Yang, Xiang-Lei, Au, Kin-Fai, Wong, Wing Hung, Guo, Min, Zhang, Mingjie, Schimmel, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188629/
https://ncbi.nlm.nih.gov/pubmed/25035493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1252943
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