Vesiculovirus Neutralization by Natural IgM and Complement

Because of its very low human seroprevalence, vesicular stomatitis virus (VSV) has promise as a systemic oncolytic agent for human cancer therapy. However, as demonstrated in this report, the VSV infectious titer drops by 4 log units during the first hour of exposure to nonimmune human serum. This n...

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Bibliografiske detaljer
Main Authors: Tesfay, Mulu Z., Ammayappan, Arun, Federspiel, Mark J., Barber, Glen N., Stojdl, David, Peng, Kah-Whye, Russell, Stephen J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Gene Delivery
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4093862/
https://ncbi.nlm.nih.gov/pubmed/24648451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00074-14
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