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Impact of Natural IgM Concentration on Gene Therapy with Adenovirus Type 5 Vectors
Natural IgM inhibits gene transfer by adenovirus type 5 (Ad5) vectors. We show that polyreactive natural IgM antibodies bind to Ad5 and that inhibition of liver transduction by IgM depends on Kupffer cells. By manipulating IgM concentration in vivo, we demonstrate that IgM inhibits liver transductio...
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| Publicado no: | J Virol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4337529/ https://ncbi.nlm.nih.gov/pubmed/25552715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03217-14 |
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