Impact of Natural IgM Concentration on Gene Therapy with Adenovirus Type 5 Vectors

Natural IgM inhibits gene transfer by adenovirus type 5 (Ad5) vectors. We show that polyreactive natural IgM antibodies bind to Ad5 and that inhibition of liver transduction by IgM depends on Kupffer cells. By manipulating IgM concentration in vivo, we demonstrate that IgM inhibits liver transductio...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Virol
Päätekijät: Qiu, Qi, Xu, Zhili, Tian, Jie, Moitra, Rituparna, Gunti, Sreenivasulu, Notkins, Abner L., Byrnes, Andrew P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2014
Aiheet:
Gene Delivery
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337529/
https://ncbi.nlm.nih.gov/pubmed/25552715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03217-14
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