Acquired Resistance of Mycobacterium tuberculosis to Bedaquiline

Bedaquiline (BDQ), an ATP synthase inhibitor, is the first drug to be approved for treatment of multi-drug resistant tuberculosis in decades. In vitro resistance to BDQ was previously shown to be due to target-based mutations. Here we report that non-target based resistance to BDQ, and cross-resista...

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Main Authors: Andries, Koen, Villellas, Cristina, Coeck, Nele, Thys, Kim, Gevers, Tom, Vranckx, Luc, Lounis, Nacer, de Jong, Bouke C., Koul, Anil
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4092087/
https://ncbi.nlm.nih.gov/pubmed/25010492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102135
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