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Bactericidal Potencies of New Regimens Are Not Predictive of Their Sterilizing Potencies in a Murine Model of Tuberculosis

TMC207, rifapentine, and moxifloxacin are in clinical testing for the treatment of tuberculosis. Five experimental regimens with various combinations of TMC207, rifapentine, moxifloxacin, and pyrazinamide were tested for their bactericidal and sterilizing potencies in Swiss mice intravenously inocul...

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Autors principals: Andries, Koen, Gevers, Tom, Lounis, Nacer
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976132/
https://ncbi.nlm.nih.gov/pubmed/20713662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00934-10
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