Impact of Fluoroquinolone Resistance on Bactericidal and Sterilizing Activity of a Moxifloxacin-Containing Regimen in Murine Tuberculosis

It has been shown previously that fluoroquinolone resistance (defined by resistance to at least 2 mg/liter ofloxacin) has a different impact on moxifloxacin monotherapy depending on the mutation in the sole fluoroquinolone target in Mycobacterium tuberculosis, i.e., DNA gyrase. Since tuberculosis tr...

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Main Authors: Fillion, Aurélie, Aubry, Alexandra, Brossier, Florence, Chauffour, Aurélie, Jarlier, Vincent, Veziris, Nicolas
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754299/
https://ncbi.nlm.nih.gov/pubmed/23836169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00506-13
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