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Expanding the binding envelope of CYP51 inhibitors targeting Trypanosoma cruzi with 4-aminopyridyl-based sulfonamide derivatives

Chagas disease is a chronic infection caused by the protozoan parasite Trypanosoma cruzi, manifested in progressive cardiomyopathy and/or gastrointestinal dysfunction. Therapeutic options to prevent or treat Chagas disease are limited. CYP51, the enzyme key to the biosynthesis of eukaryotic membrane...

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Bibliografiska uppgifter
Huvudupphovsmän: Vieira, Debora F., Choi, Jun Yong, Roush, William R., Podust, Larissa M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091728/
https://ncbi.nlm.nih.gov/pubmed/24771705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402027
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