Tryptophan Catabolism Restricts IFN-γ-expressing Neutrophils and Clostridium difficile Immunopathology

The interplay between Clostridium difficile and the host's metabolome is believed to influence the severity of infection. However, the mechanism for this phenomenon remains unclear. In this study we model one of these metabolic pathways by focussing on tryptophan metabolism in the host. We foun...

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Detalhes bibliográficos
Main Authors: El-Zaatari, Mohamad, Chang, Yu-Ming, Zhang, Min, Franz, Matthew, Shreiner, Andrew, McDermott, Andrew J., van der Sluijs, Koenraad F., Lutter, René, Grasberger, Helmut, Kamada, Nobuhiko, Young, Vincent B., Huffnagle, Gary B., Kao, John Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091639/
https://ncbi.nlm.nih.gov/pubmed/24935925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302913
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